Development and Production of Oil-in-Water Vehicles Sub- micron Emulsion the Dermal Application of Ectoin

Micro/sub-micron emulsion and related systems have received a lot of attention in the last years for their common use as vehicles for topical administration. These systems can be defined as fine emulsion dispersion with droplet sizes in the sub-micron range, and consisted of an aqueous phase, oily phase, and surfactants that are necessary for stabilizing the interface and forming the drops [1]. The main advantages of such systems are due to the high solubility as well as bioavailability potential for lipophilic and hydrophilic substance. Moreover, the emulsion ingredients (oil and surfactants) may enhance the absorption into the skin by interact with the lipids barrier of the stratum corneum to facilitate the molecule to the skin [2].